Flavonoids with M1 muscarinic acetylcholine receptor binding activity

• Main Authors: Swaminathan, M., Chee, C.F., Chin, S.P., Buckle, M.J.C., Rahman, N.A., Doughty, S.W., Chung, L.Y.
• Format: Article
• Language: English
• Published: 2017
• Subjects: Alzheimer's disease; Binding activity; Flavonoids

Muscarinic acetylcholine receptor- Active compounds have potential for the treatment of Alzheimer's disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at human cloned M1 muscarinic receptors. Sev...