A novel in vitro potency assay of antisera against Thai Naja kaouthia based on nicotinic acetylcholine receptor binding

• Main Authors: Ratanabanangkoon, K., Simsiriwong, P., Pruksaphon, K., Tan, K.Y., Eursakun, S., Tan, C.H., Chantrathonkul, B., Wongwadhunyoo, W., Youngchim, S., Tan, N.H.
• Format: Article
• Language: English
• Published: Nature Publishing Group 2017
• Subjects: R Medicine; RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/19045/1/A_novel_in_vitro_potency_assay_of_antisera_against_Thai_Naja_kaouthia_based_on_nicotinic_acetylcholine_receptor_binding.pdf; http://eprints.um.edu.my/19045/; http://dx.doi.org/10.1038/s41598-017-08962-3

Snake envenomation is an important medical problem. One of the hurdles in antivenom development is the in vivo assay of antivenom potency which is expensive, gives variable results and kills many animals. We report a novel in vitro assay involving the specific binding of the postsynaptic neurotoxins...