An in vitro potency assay using nicotinic acetylcholine receptor binding works well with antivenoms against Bungarus candidus and Naja naja

• Main Authors: Ratanabanangkoon, K., Simsiriwong, P., Pruksaphon, K., Tan, K.Y., Chantrathonkul, B., Eursakun, S., Tan, C.H.
• Format: Article
• Language: English
• Published: Nature Publishing Group 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/18981/1/An_in_vitro_potency_assay_using_nicotinic_acetylcholine_receptor_binding_works_well_with_antivenoms_against_Bungarus_candidus_and_Naja_naja.pdf; http://eprints.um.edu.my/18981/; http://dx.doi.org/10.1038/s41598-018-27794-3

In order to facilitate/expedite the production of effective and affordable snake antivenoms, a novel in vitro potency assay was previously developed. The assay is based on an antiserum's ability to bind to postsynaptic neurotoxin (PSNT) and thereby inhibit the PSNT binding to the nicotinic acet...