Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia

• Main Authors: Nan, Jiun Yap, Indra, Vythilingam, Boon, Peng Hoh, Xiang, Ting Goh, Azdayanti, Muslim, Romano, Ngui, Yamuna, Rajoo, Seow, Huey Choy, Timothy, William, Tsin, Wen Yeo, Yvonne Ai Lian, Lim
• Format: Article
• Language: English
• Published: BioMed Central Ltd 2018
• Subjects: QR Microbiology
• Online Access: http://ir.unimas.my/id/eprint/42142/1/Genetic%20polymorphism.pdf; http://ir.unimas.my/id/eprint/42142/; https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-3234-5; https://doi.org/10.1186/s13071-018-3234-5

Background: The merozoite surface protein-1 (MSP-1) gene encodes for a leading malaria vaccine candidate antigen. However, its extensive polymorphic nature represents a major obstacle to the development of a protective vaccine. Previously, a pilot study was carried out to explore the sequence varia...