Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia

• Main Authors: Yap, Nan Jiun, Vythilingam, Indra, Hoh, Boon Peng, Goh, Xiang Ting, Muslim, Azdayanti, Ngui, Romano, Rajoo, Yamuna, Choy, Seow Huey, William, Timothy, Yeo, Tsin Wen, Lim, Yvonne Ai Lian
• Format: Article
• Published: BMC 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/20310/; https://doi.org/10.1186/s13071-018-3234-5

Background: The merozoite surface protein-1 (MSP-1) gene encodes for a leading malaria vaccine candidate antigen. However, its extensive polymorphic nature represents a major obstacle to the development of a protective vaccine. Previously, a pilot study was carried out to explore the sequence variat...