Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei

• Main Authors: Carina M., Hall, Nawarat, Somprasong, Johannah P., Hagen, Roxanne, Nottingham, Jason W., Sahl, Jessica R., Webb, Mark, Mayo, Bart J., Currie, Yuwana, Podin, David M., Wagner, Paul, Keim, Herbert P., Schweizer
• Format: Article
• Language: English
• Published: American Society For Microbiology 2023
• Subjects: Q Science (General); QR Microbiology; RB Pathology
• Online Access: http://ir.unimas.my/id/eprint/41822/1/Exploring%20Cefiderocol%20Resistance%20Mechanisms%20in%20Burkholderia%20pseudomallei.pdf; http://ir.unimas.my/id/eprint/41822/; https://journals.asm.org/doi/epub/10.1128/aac.00171-23

Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistan...