Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei

• Main Authors: Carina M., Hall, Nawarat, Somprasong, Johannah P., Hagen, Roxanne, Nottingham, Jason W., Sahl, Jessica R., Webb, Mark, Mayo, Bart J., Currie, Yuwana, Podin, David M., Wagner, Paul, Keim, Herbert P., Schweizer
• Format: Article
• Language: English
• Published: American Society For Microbiology 2023
• Subjects: Q Science (General); QR Microbiology; RB Pathology
• Online Access: http://ir.unimas.my/id/eprint/41822/1/Exploring%20Cefiderocol%20Resistance%20Mechanisms%20in%20Burkholderia%20pseudomallei.pdf; http://ir.unimas.my/id/eprint/41822/; https://journals.asm.org/doi/epub/10.1128/aac.00171-23

Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.