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Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei

Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistan...

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Bibliographic Details
Main Authors: Carina M., Hall, Nawarat, Somprasong, Johannah P., Hagen, Roxanne, Nottingham, Jason W., Sahl, Jessica R., Webb, Mark, Mayo, Bart J., Currie, Yuwana, Podin, David M., Wagner, Paul, Keim, Herbert P., Schweizer
Format: Article
Language:English
Published: American Society For Microbiology 2023
Subjects:
Q Science (General)
QR Microbiology
RB Pathology
Online Access:http://ir.unimas.my/id/eprint/41822/1/Exploring%20Cefiderocol%20Resistance%20Mechanisms%20in%20Burkholderia%20pseudomallei.pdf
http://ir.unimas.my/id/eprint/41822/
https://journals.asm.org/doi/epub/10.1128/aac.00171-23
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Summary:Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.

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