Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus

• Main Author: Siti Nor Khadijah Addis
• Format: Thesis
• Language: English
• Published: Australian national University 2012
• Subjects: QP 609 .P78 S5 2011; Siti Nor Khadijah Addis; Tesis The Australian National University 2011; Proteolytic enzymes
• Online Access: http://hdl.handle.net/123456789/1653

Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic...