Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic...
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Australian national University
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my.umt.ir-16532012-07-24T03:18:23Z Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus Siti Nor Khadijah Addis QP 609 .P78 S5 2011 Siti Nor Khadijah Addis Tesis The Australian National University 2011 Proteolytic enzymes Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic cleavage events play a central role in the process of viral gene expression in flaviviruses. Despite the importance of these events, the mechanism of proteolytic cleavage leading to the generation of the two non-structural proteins, NS1 and NS2A is poorly defined. 2012-07-24T03:18:23Z 2012-07-24T03:18:23Z 2011-11 Thesis http://hdl.handle.net/123456789/1653 en ;QP 609 .P78 S5 2011 application/pdf application/pdf Australian national University |
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QP 609 .P78 S5 2011 Siti Nor Khadijah Addis Tesis The Australian National University 2011 Proteolytic enzymes |
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QP 609 .P78 S5 2011 Siti Nor Khadijah Addis Tesis The Australian National University 2011 Proteolytic enzymes Siti Nor Khadijah Addis Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus |
description |
Flaviviruses are a group of positive-strand RNA viruses of global significance. The
flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded
proteases prior to protein maturation. Hence, the proteolytic cleavage events play a central role in the process of viral gene expression in flaviviruses. Despite the importance of these events, the mechanism of proteolytic cleavage leading to the generation of the two non-structural proteins, NS1 and NS2A is poorly defined. |
format |
Thesis |
author |
Siti Nor Khadijah Addis |
author_facet |
Siti Nor Khadijah Addis |
author_sort |
Siti Nor Khadijah Addis |
title |
Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus |
title_short |
Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus |
title_full |
Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus |
title_fullStr |
Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus |
title_full_unstemmed |
Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus |
title_sort |
genetic and functional analysis of the proteolytic cleavage at the junction of the ns1 and ns2a proteins of murray valley encephalitis virus |
publisher |
Australian national University |
publishDate |
2012 |
url |
http://hdl.handle.net/123456789/1653 |
_version_ |
1738395410324520960 |
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13.18916 |