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Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus

Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic...

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Main Author: Siti Nor Khadijah Addis
Format: Thesis
Language:English
Published: Australian national University 2012
Subjects:
QP 609 .P78 S5 2011
Siti Nor Khadijah Addis
Tesis The Australian National University 2011
Proteolytic enzymes
Online Access:http://hdl.handle.net/123456789/1653
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id my.umt.ir-1653
record_format eprints
spelling my.umt.ir-16532012-07-24T03:18:23Z Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus Siti Nor Khadijah Addis QP 609 .P78 S5 2011 Siti Nor Khadijah Addis Tesis The Australian National University 2011 Proteolytic enzymes Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic cleavage events play a central role in the process of viral gene expression in flaviviruses. Despite the importance of these events, the mechanism of proteolytic cleavage leading to the generation of the two non-structural proteins, NS1 and NS2A is poorly defined. 2012-07-24T03:18:23Z 2012-07-24T03:18:23Z 2011-11 Thesis http://hdl.handle.net/123456789/1653 en ;QP 609 .P78 S5 2011 application/pdf application/pdf Australian national University
institution Universiti Malaysia Terengganu
building Perpustakaan Sultanah Nur Zahirah
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Terengganu
content_source UMT-IR
url_provider http://umt-ir.umt.edu.my:8080/
language English
topic QP 609 .P78 S5 2011
Siti Nor Khadijah Addis
Tesis The Australian National University 2011
Proteolytic enzymes
spellingShingle QP 609 .P78 S5 2011
Siti Nor Khadijah Addis
Tesis The Australian National University 2011
Proteolytic enzymes
Siti Nor Khadijah Addis
Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
description Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic cleavage events play a central role in the process of viral gene expression in flaviviruses. Despite the importance of these events, the mechanism of proteolytic cleavage leading to the generation of the two non-structural proteins, NS1 and NS2A is poorly defined.
format Thesis
author Siti Nor Khadijah Addis
author_facet Siti Nor Khadijah Addis
author_sort Siti Nor Khadijah Addis
title Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
title_short Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
title_full Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
title_fullStr Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
title_full_unstemmed Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
title_sort genetic and functional analysis of the proteolytic cleavage at the junction of the ns1 and ns2a proteins of murray valley encephalitis virus
publisher Australian national University
publishDate 2012
url http://hdl.handle.net/123456789/1653
_version_ 1738395410324520960
score 13.222552

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