Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic...
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| Format: | Thesis |
| Language: | English |
| Published: |
Australian national University
2012
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| Subjects: | |
| Online Access: | http://hdl.handle.net/123456789/1653 |
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| Summary: | Flaviviruses are a group of positive-strand RNA viruses of global significance. The
flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded
proteases prior to protein maturation. Hence, the proteolytic cleavage events play a central role in the process of viral gene expression in flaviviruses. Despite the importance of these events, the mechanism of proteolytic cleavage leading to the generation of the two non-structural proteins, NS1 and NS2A is poorly defined. |
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