Dual anti-malarial and GSK3β-mediated cytokine-modulating activities of quercetin are requisite of its potential as a plant-derived therapeutic in malaria

• Main Authors: Amatul Hamizah Ali, Suhaini Sudi, Ng, Shi-Jing, Wan Rozianoor Mohd Hassan, Rusliza Basir, Hani Kartini Agustar, Noor Embi, Hasidah Mohd Sidek, Jalifah Latip
• Format: Article
• Language: English
• Published: Multidisciplinary Digital Publishing Institute 2021
• Subjects: RA643-645 Disease (Communicable and noninfectious) and public health; RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
• Online Access: https://eprints.ums.edu.my/id/eprint/42449/1/FULL%20TEXT.pdf; https://eprints.ums.edu.my/id/eprint/42449/; https://doi.org/10.3390/ph14030248

Although death in malaria is attributed to cerebrovascular blockage and anaemia, overwhelming cytokine production can contribute to the severity of the disease. Therefore, mitigation of dysregulated inflammatory signalling may provide further benefit for malaria treatment. Quercetin (3,3′,4′,5,7-pen...