Insights from in silico exploration of major curcumin analogs targeting human dipeptidyl peptidase IV

• Main Authors: Roney, Miah, Dubey, Amit, Issahaku, Abdul Rashid, Uddin, Md. Nazim, Tufail, Aisha, Wilhelm, Anke, Normaiza, Zamri, Mohd Fadhlizil Fasihi, Mohd Aluwi
• Format: Article
• Language: English; English
• Published: Taylor & Francis 2024
• Subjects: HD Industries. Land use. Labor; TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/41689/1/Insights%20from%20in%20silico%20exploration%20of%20major%20curcumin%20analogs%20targeting%20human%20dipeptidyl.pdf; http://umpir.ump.edu.my/id/eprint/41689/2/Insights%20from%20in%20silico%20exploration%20of%20major%20curcumin%20analogs%20targeting%20human%20dipeptidyl%20peptidase%20IV.pdf; http://umpir.ump.edu.my/id/eprint/41689/; https://doi.org/10.1080/07391102.2024.2306197

The goal of this work is to use a variety of in-silico techniques to identify anti-diabetic agents against DPP-IV enzyme from five main curcumin analogues. To produce the successful molecules, five main curcumin analogues were docked into the active site of DPP-IV enzyme. In comparison to the contro...