Pharmacophore-based virtual screening and in-silico study of natural products as potential DENV-2 RdRp inhibitors

• Main Authors: Miah, Roney, A. K. M., Moyeenul Huq, Abdul Rashid, Issahaku, Mahmoud E. S., Soliman, Md. Sanower, Hossain, Abu Hasnat, Mustafa, Md. Alimul, Islam, Amit, Dubey, Aisha, Tufail, Mohd Fadhlizil Fasihi, Mohd Aluwi, Saiful Nizam, Tajuddin
• Format: Article
• Language: English; English
• Published: Taylor & Francis 2023
• Subjects: Q Science (General); R Medicine (General); T Technology (General)
• Online Access: http://umpir.ump.edu.my/id/eprint/37892/1/Pharmacophore-based%20virtual%20screening%20and%20in-silico%20study.pdf; http://umpir.ump.edu.my/id/eprint/37892/2/Pharmacophore-based%20virtual%20screening%20and%20in-silico%20study%20of%20natural%20products%20as%20potential%20DENV-2%20RdRp%20inhibitors.pdf; http://umpir.ump.edu.my/id/eprint/37892/; https://doi.org/10.1080/07391102.2023.2166123; https://doi.org/10.1080/07391102.2023.2166123

Dengue fever is a significant public health concern throughout the world, causing an estimated 500,000 hospitalizations and 20,000 deaths each year, despite the lack of effective therapies. The DENV-2 RdRp has been identified as a potential target for the development of new and effective dengue ther...