Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA

• Main Authors: Mohd F. F., Mohd Aluwi, Rullah, Kamal, Koeberle, Andreas, Werz, Oliver, Nur Sakinah, Abdul Razak, Wei, Leong Sze, Fatimah, Salim, Nor Hadiani, Ismail, Ibrahim, Jantan, Wai, Lam K.
• Format: Article
• Language: English
• Published: Elsevier Ltd 2019
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://umpir.ump.edu.my/id/eprint/25636/1/Design%20and%20synthesis%20of%20a%20novel%20mPGES-1%20lead%20inhibitor%20.pdf; http://umpir.ump.edu.my/id/eprint/25636/; https://doi.org/10.1016/j.molstruc.2019.07.004; https://doi.org/10.1016/j.molstruc.2019.07.004

The search of novel mPGES-1 inhibitors has recently intensified probably due to the superior safety in comparison to existing anti-inflammatory drugs. Although two mPGES-1 inhibitors have entered clinical trials, none has yet reached the market. In this study, we performed modifications guided by 3D...