Development, Validation and Pharmacokinetic Application of a Simple and Robust RP-HPLC Method for Quantitation of Raloxifene in Rat Plasma

• Main Authors: Mahmood, Syed, Sengupta, Pinaki, Mandal, Uttam K., Chatterjee, Bappaditya, Taher, Muhammad
• Format: Article
• Language: English
• Published: College of Pharmacists of Buenos Aires Province, Argentina 2017
• Subjects: RS Pharmacy and materia medica
• Online Access: http://umpir.ump.edu.my/id/eprint/19791/1/ftech-2017-mahmood-Development%2C%20Validation%20and%20Pharmacokinetic%20Application1.pdf; http://umpir.ump.edu.my/id/eprint/19791/; http://www.latamjpharm.org/resumenes/36/9/LAJOP_36_9_1_35.pdf; http://www.latamjpharm.org/previous_issue.php?vol=36&num=9

SUMMARY. A simple and sensitive HPLC method has been developed and validated for the quantification of raloxifene in rat plasma. Liquid- liquid extraction procedure was employed for extracting raloxifene from rat plasma sample. Separation of raloxifene was achieved through a RP- C18 column with a...