Development and validation of a high throughput LC–MS/MS method for simultaneous quantitation of pioglitazone and telmisartan in rat plasma and its application to a pharmacokinetic study

• Main Authors: Sengupta, Pinaki, Chatterjee, Bappaditya, Mandal, Uttam Kumar, Gorain, Bapi, Pal, Tapan Kumar
• Format: Article
• Language: English; English
• Published: Xi'an Jiaotong University 2017
• Subjects: RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/57104/12/57104_Development%20and%20validation%20of%20a%20high%20throughput_article.pdf; http://irep.iium.edu.my/57104/7/A%20high%20throughput%20LC-MS%20MS%20method%20for%20simultaneous%20quantitation%20of%20pioglitazone%20and%20telmisartan%20in%20rat%20plasma%20development%2C%20validation%20and%20pharmacokinetic%20application.pdf; http://irep.iium.edu.my/57104/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790748/pdf/main.pdf

Management of cardiovascular risk factors in diabetes demands special attention due to their co-existence. Pioglitazone (PIO) and telmisartan (TLM) combination can be beneficial in effective control of cardiovascular complication in diabetes. In this research, we developed and validated a high thr...