Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II mediated BMP4 oxidative stress cascade

• Main Authors: Lau, Y.S., Tian, X.Y., Mustafa, Mohd Rais, Murugan, D., Liu, J., Zhang, Y., Lau, C.W., Huang, Y.
• Format: Article
• Published: Nature Publishing Group 2013
• Subjects: R Medicine; RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/9801/; http://onlinelibrary.wiley.com/doi/10.1111/bph.12350/full

BACKGROUND AND PURPOSE: Boldine is a potent natural antioxidant present in the leaves and bark of the Chilean boldo tree. Here we assessed the protective effects of boldine on endothelium in a range of models of diabetes, ex vivo and in vitro. EXPERIMENTAL APPROACH: Vascular reactivity was studied i...