The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats

• Main Authors: Lau, Yeh-Siang, Machha, A., Achike, F.I., Mustafa, Mohd Rais, Murugan, D.
• Format: Article
• Language: English
• Published: 2011
• Subjects: R Medicine; RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/2413/1/Experimental_Biology_and_Medicine_2011__1%E2%80%93_6.pdf; http://eprints.um.edu.my/2413/; http://ebm.rsmjournals.com/content/early/2011/12/06/ebm.2011.011145.long

Boldine, a major aporphine alkaloid found in Chilean boldo tree, is a potent antioxidant. Oxidative stress plays a detrimentalrole in the pathogenesis of endothelial dysfunction in hypertension. In the present study, we investigated the effects of boldine on endothelial dysfunction in hypertension u...