A search for dengue 2 virus inhibitor from tripeptides and hexapeptides
Libraries of tripeptides and hexapeptides were screened for inhibitory activity against the dengue protease complex. Libraries of tripeptide showed very weak inhibition towards dengue protease, On the other hand, libraries of hexapeptide, designed based on substrate-based inhibitors, where basic ami...
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Faculty of Science, University of Malaya
2005
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my.um.eprints.71422018-10-10T06:53:41Z http://eprints.um.edu.my/7142/ A search for dengue 2 virus inhibitor from tripeptides and hexapeptides Abd Rahman, Noorsaadah Kt, Teoh Yusof, Rohana R Medicine Libraries of tripeptides and hexapeptides were screened for inhibitory activity against the dengue protease complex. Libraries of tripeptide showed very weak inhibition towards dengue protease, On the other hand, libraries of hexapeptide, designed based on substrate-based inhibitors, where basic amino acids, such as arginine or lysine at the P1 position incorporated with non-coded amino acids, showed an increase in potency. The library H2L1 was the most promising candidate with 33.0 inhibition (8.0 mg/ml), but library H2L2 (2.0mg/ml) possesses considerably weak inhibition. On theother hand, library H2L3 showed 21.3 inhibition against the protease activity. Overall, libraries of hexapeptide were considered weak in inhibitory effect although they showed better inhibitory activities than the tripeptide libraries. Although the inhibitory activities of these peptide libraries are in the mg/mL range, the combinatorial library synthesized has provided indispensable information towards the design of possible inhibitors. Faculty of Science, University of Malaya 2005 Article PeerReviewed Abd Rahman, Noorsaadah and Kt, Teoh and Yusof, Rohana (2005) A search for dengue 2 virus inhibitor from tripeptides and hexapeptides. Malaysian Journal of Science, 24 (2). pp. 13-20. ISSN 1394-3065 https://ejournal.um.edu.my/index.php/MJS/article/view/8298 |
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R Medicine Abd Rahman, Noorsaadah Kt, Teoh Yusof, Rohana A search for dengue 2 virus inhibitor from tripeptides and hexapeptides |
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Libraries of tripeptides and hexapeptides were screened for inhibitory activity against the dengue protease complex. Libraries of tripeptide showed very weak inhibition towards dengue protease, On the other hand, libraries of hexapeptide, designed based on substrate-based inhibitors, where basic amino acids, such as arginine or lysine at the P1 position incorporated with non-coded amino acids, showed an increase in potency. The library H2L1 was the most promising candidate with 33.0 inhibition (8.0 mg/ml), but library H2L2 (2.0mg/ml) possesses considerably weak inhibition. On theother hand, library H2L3 showed 21.3 inhibition against the protease activity. Overall, libraries of hexapeptide were considered weak in inhibitory effect although they showed better inhibitory activities than the tripeptide libraries. Although the inhibitory activities of these peptide libraries are in the mg/mL range, the combinatorial library synthesized has provided indispensable information towards the design of possible inhibitors. |
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Article |
author |
Abd Rahman, Noorsaadah Kt, Teoh Yusof, Rohana |
author_facet |
Abd Rahman, Noorsaadah Kt, Teoh Yusof, Rohana |
author_sort |
Abd Rahman, Noorsaadah |
title |
A search for dengue 2 virus inhibitor from tripeptides and hexapeptides |
title_short |
A search for dengue 2 virus inhibitor from tripeptides and hexapeptides |
title_full |
A search for dengue 2 virus inhibitor from tripeptides and hexapeptides |
title_fullStr |
A search for dengue 2 virus inhibitor from tripeptides and hexapeptides |
title_full_unstemmed |
A search for dengue 2 virus inhibitor from tripeptides and hexapeptides |
title_sort |
search for dengue 2 virus inhibitor from tripeptides and hexapeptides |
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Faculty of Science, University of Malaya |
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2005 |
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http://eprints.um.edu.my/7142/ https://ejournal.um.edu.my/index.php/MJS/article/view/8298 |
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