Germline APOBEC3B deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, PIK3CA mutations and immune activation

• Main Authors: Pan, Jia-Wern, Zabidi, Muhammad Mamduh Ahmad, Chong, Boon-Keat, Meng, Mei-Yee, Ng, Pei-Sze, Hasan, Siti Norhidayu, Sandey, Bethan, Bahnu, Saira, Rajadurai, Pathmanathan, Yip, Cheng-Har, Rueda, Oscar M., Caldas, Carlos, Chin, Suet-Feung, Teo, Soo-Hwang
• Format: Article
• Published: John Wiley & Sons 2021
• Subjects: HT Communities. Classes. Races; R Medicine; R Medicine (General)
• Online Access: http://eprints.um.edu.my/34553/

A 30-kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian descent compared to European descent. This polymorphism creates a chimera with the APOBEC3A (A3A) coding region and A3B 3 ` UTR, and it is associated with an increased risk for breast ca...