Vaccine candidates generated by codon and codon pair deoptimization of enterovirus A71 protect against lethal challenge in mice

• Main Authors: Lee, Michelle Hui Pheng, Tan, Chee Wah, Tee, Han Kang, Ong, Kien Chai, Sam, I-Ching, Chan, Yoke Fun
• Format: Article
• Published: Elsevier Sci Ltd 2021
• Subjects: R Medicine (General)
• Online Access: http://eprints.um.edu.my/28520/

Enterovirus A71 (EV-A71) causes hand, foot and mouth disease (HFMD) in young children. It is associated with severe neurological complications and death. This study aims to develop a live-attenuated vaccine by codon deoptimization (CD) and codon-pair deoptimization (CPD) of EV-A71. CD is generated b...