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LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-kappa B and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced Neuroprotection

Neuroinflammation, an inflammatory response within the nervous system, has been shown to be implicated in the progression of various neurodegenerative diseases. Recent in vivo studies showed that lipopolysaccharide (LPS) preconditioning provides neuroprotection by activating Toll-like receptor 4 (TL...

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Main Authors: Sangaran, Pushpa Gandi, Ibrahim, Zaridatul Aini, Chik, Zamri, Mohamed, Zahurin, Ahmadiani, Abolhassan
Format: Article
Published: Springer 2021
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/28002/
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spelling my.um.eprints.280022022-07-06T08:09:02Z http://eprints.um.edu.my/28002/ LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-kappa B and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced Neuroprotection Sangaran, Pushpa Gandi Ibrahim, Zaridatul Aini Chik, Zamri Mohamed, Zahurin Ahmadiani, Abolhassan R Medicine (General) Neuroinflammation, an inflammatory response within the nervous system, has been shown to be implicated in the progression of various neurodegenerative diseases. Recent in vivo studies showed that lipopolysaccharide (LPS) preconditioning provides neuroprotection by activating Toll-like receptor 4 (TLR4), one of the members for pattern recognition receptor (PRR) family that play critical role in host response to tissue injury, infection, and inflammation. Pre-exposure to low dose of LPS could confer a protective state against cellular apoptosis following subsequent stimulation with LPS at higher concentration, suggesting a role for TLR4 pre-activation in the signaling pathway of LPS-induced neuroprotection. However, the precise molecular mechanism associated with this protective effect is not well understood. In this article, we provide an overall review of the current state of our knowledge about LPS preconditioning in attenuating apoptosis mechanism and conferring neuroprotection via TLR4 signaling pathway. Springer 2021-05 Article PeerReviewed Sangaran, Pushpa Gandi and Ibrahim, Zaridatul Aini and Chik, Zamri and Mohamed, Zahurin and Ahmadiani, Abolhassan (2021) LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-kappa B and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced Neuroprotection. Molecular Neurobiology, 58 (5). pp. 2407-2422. ISSN 0893-7648, DOI https://doi.org/10.1007/s12035-020-02227-3 <https://doi.org/10.1007/s12035-020-02227-3>. 10.1007/s12035-020-02227-3
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Sangaran, Pushpa Gandi
Ibrahim, Zaridatul Aini
Chik, Zamri
Mohamed, Zahurin
Ahmadiani, Abolhassan
LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-kappa B and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced Neuroprotection
description Neuroinflammation, an inflammatory response within the nervous system, has been shown to be implicated in the progression of various neurodegenerative diseases. Recent in vivo studies showed that lipopolysaccharide (LPS) preconditioning provides neuroprotection by activating Toll-like receptor 4 (TLR4), one of the members for pattern recognition receptor (PRR) family that play critical role in host response to tissue injury, infection, and inflammation. Pre-exposure to low dose of LPS could confer a protective state against cellular apoptosis following subsequent stimulation with LPS at higher concentration, suggesting a role for TLR4 pre-activation in the signaling pathway of LPS-induced neuroprotection. However, the precise molecular mechanism associated with this protective effect is not well understood. In this article, we provide an overall review of the current state of our knowledge about LPS preconditioning in attenuating apoptosis mechanism and conferring neuroprotection via TLR4 signaling pathway.
format Article
author Sangaran, Pushpa Gandi
Ibrahim, Zaridatul Aini
Chik, Zamri
Mohamed, Zahurin
Ahmadiani, Abolhassan
author_facet Sangaran, Pushpa Gandi
Ibrahim, Zaridatul Aini
Chik, Zamri
Mohamed, Zahurin
Ahmadiani, Abolhassan
author_sort Sangaran, Pushpa Gandi
title LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-kappa B and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced Neuroprotection
title_short LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-kappa B and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced Neuroprotection
title_full LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-kappa B and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced Neuroprotection
title_fullStr LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-kappa B and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced Neuroprotection
title_full_unstemmed LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-kappa B and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced Neuroprotection
title_sort lps preconditioning attenuates apoptosis mechanism by inhibiting nf-kappa b and caspase-3 activity: tlr4 pre-activation in the signaling pathway of lps-induced neuroprotection
publisher Springer
publishDate 2021
url http://eprints.um.edu.my/28002/
_version_ 1738510686282055680
score 13.18916

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