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Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis

Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 al...

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Main Authors: Gan, Chew Yan, Low, Yun Yee, Etoh, Tadahiro, Hayashi, Masahiko, Komiyama, Kanki, Kam, Toh Seok
Format: Article
Published: American Chemical Society 2009
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.um.edu.my/25657/
https://doi.org/10.1021/np900576b
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spelling my.um.eprints.256572020-12-14T05:34:10Z http://eprints.um.edu.my/25657/ Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis Gan, Chew Yan Low, Yun Yee Etoh, Tadahiro Hayashi, Masahiko Komiyama, Kanki Kam, Toh Seok Q Science (General) QD Chemistry Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 also by partial synthesis. Alkaloids 1-5 reversed multidrug resistance in vincristine-resistant KB cells. © 2009 American Chemical Society and American Society of Pharmacognosy. American Chemical Society 2009 Article PeerReviewed Gan, Chew Yan and Low, Yun Yee and Etoh, Tadahiro and Hayashi, Masahiko and Komiyama, Kanki and Kam, Toh Seok (2009) Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis. Journal of Natural Products, 72 (12). pp. 2098-2103. ISSN 0163-3864 https://doi.org/10.1021/np900576b doi:10.1021/np900576b
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Gan, Chew Yan
Low, Yun Yee
Etoh, Tadahiro
Hayashi, Masahiko
Komiyama, Kanki
Kam, Toh Seok
Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis
description Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 also by partial synthesis. Alkaloids 1-5 reversed multidrug resistance in vincristine-resistant KB cells. © 2009 American Chemical Society and American Society of Pharmacognosy.
format Article
author Gan, Chew Yan
Low, Yun Yee
Etoh, Tadahiro
Hayashi, Masahiko
Komiyama, Kanki
Kam, Toh Seok
author_facet Gan, Chew Yan
Low, Yun Yee
Etoh, Tadahiro
Hayashi, Masahiko
Komiyama, Kanki
Kam, Toh Seok
author_sort Gan, Chew Yan
title Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis
title_short Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis
title_full Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis
title_fullStr Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis
title_full_unstemmed Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis
title_sort leuconicines a−g and (−)-eburnamaline, biologically active strychnan and eburnan alkaloids fromleuconotis
publisher American Chemical Society
publishDate 2009
url http://eprints.um.edu.my/25657/
https://doi.org/10.1021/np900576b
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score 13.160551

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