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Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis

Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 al...

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Bibliographic Details
Main Authors: Gan, Chew Yan, Low, Yun Yee, Etoh, Tadahiro, Hayashi, Masahiko, Komiyama, Kanki, Kam, Toh Seok
Format: Article
Published: American Chemical Society 2009
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.um.edu.my/25657/
https://doi.org/10.1021/np900576b
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Summary:Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 also by partial synthesis. Alkaloids 1-5 reversed multidrug resistance in vincristine-resistant KB cells. © 2009 American Chemical Society and American Society of Pharmacognosy.

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