Molecular interaction study of an anticancer drug, ponatinib with human serum albumin using spectroscopic and molecular docking methods

• Main Authors: Tayyab, Saad, Sam, Si Enn, Kabir, Md Zahirul, Ridzwan, Nor Farrah Wahidah, Mohamad, Saharuddin
• Format: Article
• Published: Elsevier 2019
• Subjects: Q Science (General); QH Natural history; QR Microbiology
• Online Access: http://eprints.um.edu.my/23269/; https://doi.org/10.1016/j.saa.2019.02.028

Binding of a potent anticancer agent, ponatinib (PTB) to human serum albumin (HSA), main ligand transporter in blood plasma was analyzed with several spectral techniques such as fluorescence, absorption and circular dichroism along with molecular docking studies. Decrease in the K SV value with incr...