Interactive association between RhoA transcriptional signaling inhibitor, CCG1423 and human serum albumin: Biophysical and in silico studies

• Main Authors: Kabir, Md Zahirul, Ghani, Hamidah, Mohamad, Saharuddin, Alias, Zazali, Tayyab, Saad
• Format: Article
• Published: Taylor & Francis 2018
• Subjects: Q Science (General); QH Natural history
• Online Access: http://eprints.um.edu.my/21725/; https://doi.org/10.1080/07391102.2017.1360207

Multiple spectroscopic techniques, such as fluorescence, absorption, and circular dichroism along with in silico studies were used to characterize the binding of a potent inhibitor molecule, CCG1423 to the major transport protein, human serum albumin (HSA). Fluorescence and absorption spectroscopic...