Phencyclidine dose optimisation for induction of spatial learning and memory deficits related to schizophrenia in C57BL/6 mice

• Main Authors: Zain, Mohd Aizat Mohd, Rouhollahi, Elham, Pandy, Vijayapandi, Mani, Vasudevan, Majeed, Abu Bakar Abdul, Wong, Won Fen, Mohamed, Zahurin
• Format: Article
• Published: Japanese Association for Laboratory Animal Science 2018
• Subjects: R Medicine; RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/20205/; https://doi.org/10.1538/expanim.18-0006

Phencyclidine (PCP) has been used to model cognitive deficits related to schizophrenia in rats and mice. However, the model in mice is not consistent in terms of the PCP effective dose reported. Furthermore, most of the previous studies in mice excluded the presence of drug washout period in the reg...