Peripheral loss of CD8+CD161++TCRVα7·2+ mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients

• Main Authors: Barathan, M., Mohamed, R., Vadivelu, J., Chang, L.Y., Saeidi, A., Yong, Y.K., Ravishankar Ram, M., Gopal, K., Velu, V., Larsson, M., Shankar, E.M.
• Format: Article
• Published: Blackwell Publishing 2016
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/18463/; https://doi.org/10.1111/eci.12581

Background: Mucosal-associated invariant T (MAIT) cells play an important role in innate host defence. MAIT cells appear to undergo exhaustion and are functionally weakened in chronic viral infections. However, their role in chronic hepatitis C virus (HCV) infection remains unclear. Materials and me...