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Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity

Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown...

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Main Authors: Hirasawa, Y., Hara, M., Nugroho, A.E., Sugai, M., Zaima, K., Kawahara, N., Goda, Y., Awang, K., Hadi, A.H.A., Litaudon, M., Morita, H.
Format: Article
Published: American Chemical Society 2010
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R Medicine
Online Access:http://eprints.um.edu.my/13222/
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spelling my.um.eprints.132222015-04-07T08:45:19Z http://eprints.um.edu.my/13222/ Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity Hirasawa, Y. Hara, M. Nugroho, A.E. Sugai, M. Zaima, K. Kawahara, N. Goda, Y. Awang, K. Hadi, A.H.A. Litaudon, M. Morita, H. R Medicine Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown to be in an atropisomeric relationship. Bisnicalaterines B and C (1 and 2) showed potent vasorelaxant activity on isolated rat aorta. American Chemical Society 2010 Article PeerReviewed Hirasawa, Y. and Hara, M. and Nugroho, A.E. and Sugai, M. and Zaima, K. and Kawahara, N. and Goda, Y. and Awang, K. and Hadi, A.H.A. and Litaudon, M. and Morita, H. (2010) Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity. The Journal of Organic Chemistry, 75 (12). pp. 4218-4223.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Hirasawa, Y.
Hara, M.
Nugroho, A.E.
Sugai, M.
Zaima, K.
Kawahara, N.
Goda, Y.
Awang, K.
Hadi, A.H.A.
Litaudon, M.
Morita, H.
Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity
description Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown to be in an atropisomeric relationship. Bisnicalaterines B and C (1 and 2) showed potent vasorelaxant activity on isolated rat aorta.
format Article
author Hirasawa, Y.
Hara, M.
Nugroho, A.E.
Sugai, M.
Zaima, K.
Kawahara, N.
Goda, Y.
Awang, K.
Hadi, A.H.A.
Litaudon, M.
Morita, H.
author_facet Hirasawa, Y.
Hara, M.
Nugroho, A.E.
Sugai, M.
Zaima, K.
Kawahara, N.
Goda, Y.
Awang, K.
Hadi, A.H.A.
Litaudon, M.
Morita, H.
author_sort Hirasawa, Y.
title Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity
title_short Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity
title_full Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity
title_fullStr Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity
title_full_unstemmed Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity
title_sort bisnicalaterines b and c, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity
publisher American Chemical Society
publishDate 2010
url http://eprints.um.edu.my/13222/
_version_ 1643689494049718272
score 13.160551

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