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Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events

We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster w...

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Main Authors: Li, Y., Uenishi, R., Hase, S., Liao, H., Li, Xiao-Jie, Tsuchiura, T., Tee, K.K., Pybus, O.G., Takebe, Y.
Format: Article
Published: Elsevier 2010
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/12693/
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spelling my.um.eprints.126932015-02-11T06:34:05Z http://eprints.um.edu.my/12693/ Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events Li, Y. Uenishi, R. Hase, S. Liao, H. Li, Xiao-Jie Tsuchiura, T. Tee, K.K. Pybus, O.G. Takebe, Y. R Medicine We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region. (C) 2010 Elsevier Inc. All rights reserved. Elsevier 2010 Article PeerReviewed Li, Y. and Uenishi, R. and Hase, S. and Liao, H. and Li, Xiao-Jie and Tsuchiura, T. and Tee, K.K. and Pybus, O.G. and Takebe, Y. (2010) Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events. Virology, 402 (2). pp. 223-227.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Li, Y.
Uenishi, R.
Hase, S.
Liao, H.
Li, Xiao-Jie
Tsuchiura, T.
Tee, K.K.
Pybus, O.G.
Takebe, Y.
Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
description We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region. (C) 2010 Elsevier Inc. All rights reserved.
format Article
author Li, Y.
Uenishi, R.
Hase, S.
Liao, H.
Li, Xiao-Jie
Tsuchiura, T.
Tee, K.K.
Pybus, O.G.
Takebe, Y.
author_facet Li, Y.
Uenishi, R.
Hase, S.
Liao, H.
Li, Xiao-Jie
Tsuchiura, T.
Tee, K.K.
Pybus, O.G.
Takebe, Y.
author_sort Li, Y.
title Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
title_short Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
title_full Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
title_fullStr Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
title_full_unstemmed Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
title_sort explosive hiv-1 subtype b' epidemics in asia driven by geographic and risk group founder events
publisher Elsevier
publishDate 2010
url http://eprints.um.edu.my/12693/
_version_ 1643689353867689984
score 13.211869

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