Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07BC and CRF08BC in East Asia: the relevance of genetic diversity and phylodynamics for vaccine strategies

• Main Authors: Takebe, Y., Liao, H.N., Hase, S., Uenishi, R., Li, Y.E., Li, X.J., Han, X.X., Shang, H., Kamarulzaman, A., Yamamoto, N., Pybus, O.G., Tee, K.K.
• Format: Article
• Language: English
• Published: 2010
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/4613/1/Takebe-2010-Reconstructing_the_e.pdf; http://eprints.um.edu.my/4613/

HIV-1 CRF07BC and CRF08BC are closely related circulating recombinant forms (CRFs) with serious public health consequences in China. The temporal and spatial dynamics of these CRI's were determined by estimating their times of divergence, using phylogenetic and Bayesian coalescent methods. Stud...