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Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events

We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster w...

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Bibliographic Details
Main Authors: Li, Y., Uenishi, R., Hase, S., Liao, H., Li, Xiao-Jie, Tsuchiura, T., Tee, K.K., Pybus, O.G., Takebe, Y.
Format: Article
Published: Elsevier 2010
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/12693/
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Summary:We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region. (C) 2010 Elsevier Inc. All rights reserved.

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