A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines

• Main Authors: Lim, Felicia Phei Lin, Tan, Lin Yuing, Tiekink, Edward R. T. *, Dolzhenko, Anton V
• Format: Article
• Language: English
• Published: Royal Society of Chemistry 2018
• Subjects: QD Chemistry
• Online Access: http://eprints.sunway.edu.my/842/1/Tieknink%20One%20Pot%20multicomponent.pdf; http://eprints.sunway.edu.my/842/; http://doi.org/10.1039/c8ra03703e

A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-a] [1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography.