A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines
A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-a] [1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanam...
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Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Royal Society of Chemistry
2018
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Subjects: | |
Online Access: | http://eprints.sunway.edu.my/842/1/Tieknink%20One%20Pot%20multicomponent.pdf http://eprints.sunway.edu.my/842/ http://doi.org/10.1039/c8ra03703e |
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Summary: | A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-a]
[1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the
structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently
performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography. |
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