In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates

• Main Authors: Chen, Bao-Jing, Nazzatush Shimar Jamaludin,, Khoo, Chai-Hoon, See, Tian-Hong, Sim, Jiun-Horng, Cheah, Yoke-Kqueen, Siti Nadiah Abdul Halim,, Seng, Hoi-Ling *, Tiekink, Edward R. T. *
• Format: Article
• Language: English
• Published: Elsevier 2016
• Subjects: QD Chemistry
• Online Access: http://eprints.sunway.edu.my/614/1/JInorgBiochem%202016%20163%2068_Deposited.pdf; http://eprints.sunway.edu.my/614/; http://dx.doi.org/10.1016/j.jinorgbio.2016.08.002

Four compounds, R3PAu[S2CN(CH2CH2OH)2], R=Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ=Rꞌ=Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimuminhibitory concentration (MIC) scores,...