Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance

• Main Authors: Nur Syafiqah, Rahim, Wu, Yuan Seng *, Sim, Maw Shin, Vetriselvan, Subramaniyan, Choy, Ker Woon, Teow, Sin Yeang *, Ismail, M. Fareez, Chandramathi, Samudi, Shamala, Devi Sekaran, Mahendran, Sekar, Guad, Rhanye Mac
• Format: Article
• Language: English
• Published: MDPI 2023
• Subjects: QH Natural history; QP Physiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2787/1/Wu%20Yuan%20Seng_Three%20members%20of%20transmembrane-4-superfamily.pdf; http://eprints.sunway.edu.my/2787/; https://doi.org/10.3390/ph16010110

There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Physiologically, they regulate tissue differentiation, signal transduction pathways, cellular activation, proliferation, motility, adhesion, and angiogenesis. Accumulating evidence has...