Three members of transmembrane-4-superfamily, tm4sf1, Tm4sf4, and tm4sf5, as emerging anticancer molecular Targets against cancer phenotypes and chemoresistance

• Main Authors: Nur Syafiqah Rahim, Yuan Seng Wu, Maw Shin Sim, Appalaraju Velaga, Srinivasa Reddy Bonam, Subash C. B. Gopinath, Vetriselvan Subramaniyan, Ker Woon Choy, Sin-Yeang Teow, Ismail M. Fareez, Chandramathi Samudi, Shamala Devi Sekaran, Mahendran Sekar, Rhanye Mac Guad
• Format: Article
• Language: English; English
• Published: Molecular Diversity Preservation International (MDPI) 2023
• Subjects: QP501-801 Animal biochemistry; RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
• Online Access: https://eprints.ums.edu.my/id/eprint/35751/1/ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/35751/2/FULL%20%20TEXT.pdf; https://eprints.ums.edu.my/id/eprint/35751/; https://doi.org/10.3390/ph16010110

There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Physiologically, they regulate tissue differentiation, signal transduction pathways, cellular activation, proliferation, motility, adhesion, and angiogenesis. Accumulating evidence has...