Three members of transmembrane-4-superfamily, TM4SF1, TM4SF4, and TM4SF5, as emerging anticancer molecular targets against cancer phenotypes and chemoresistance

• Main Authors: Rahim, Nur Syafiqah, Wu, Yuan Seng, Sim, Maw Shin, Velaga, Appalaraju, Bonam, Srinivasa Reddy, Gopinath, Subash C. B., Subramaniyan, Vetriselvan, Choy, Ker Woon, Teow, Sin-Yeang, Fareez, Ismail M. M., Samudi, Chandramathi, Sekaran, Shamala Devi, Sekar, Mahendran, Guad, Rhanye Mac
• Format: Article
• Published: MDPI 2023
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer); RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/39094/

There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Physiologically, they regulate tissue differentiation, signal transduction pathways, cellular activation, proliferation, motility, adhesion, and angiogenesis. Accumulating evidence has...