Comparison of solvent casting and spray casting method on compounding of an orally disintegrating film containing amlodipine besylate
The amlodipine besylate tablet is one of the most highly prescribed medicines to manage hypertension in the geriatric population. However, the difficulty of swallowing tablets due to problems like dysphagia, fear of choking, and odynophagia has been identified as one of the contributing factors t...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
International Journal of Pharmaceutical Compounding (Ijpc)
2022
|
Subjects: | |
Online Access: | http://irep.iium.edu.my/98713/7/98713_Comparison%20of%20solvent%20casting%20and%20spray%20casting%20method.pdf http://irep.iium.edu.my/98713/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.iium.irep.98713 |
---|---|
record_format |
dspace |
spelling |
my.iium.irep.987132022-07-07T02:59:01Z http://irep.iium.edu.my/98713/ Comparison of solvent casting and spray casting method on compounding of an orally disintegrating film containing amlodipine besylate Ruslan, Mohamad Fariz Haiqal Janakiraman, Ashok Kumar Janakiraman Long, Chiau Ming Helal Uddin, A.B.M. Sarker, Zaidul Islam Liew, Kai Bin QD Chemistry RM300 Drugs and their action RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry The amlodipine besylate tablet is one of the most highly prescribed medicines to manage hypertension in the geriatric population. However, the difficulty of swallowing tablets due to problems like dysphagia, fear of choking, and odynophagia has been identified as one of the contributing factors to non-compliance among geriatrics. Due to the swallowing factor among geriatrics, this study was conducted to compare two compounding methods of orally disintegrating films, namely solvent casting and spray casting, to produce an orally disintegrating film containing amlodipine besylate. Different polymers were used to develop the orally disintegrating films, and the formulations were subjected to validation tests such as thickness, folding endurance, tensile strength, percentage of elongation, Young’s modulus, disintegration, and dissolution. Chemicals like hydroxypropyl methylcellulose, carboxymethyl cellulose, glycerin, mannitol, sodium lauryl sulfate, citric acid, peppermint oil, and a coloring agent were used to formulate the orally disintegrating films. In addition, orally disintegrating films were prepared using the solvent casting and the spraying method. An increase in the polymer’s concentration resulted in the formation of a greater mechanical strength. After a comparison between the hydroxypropyl methylcellulose and the carboxymethyl cellulose as film-forming agents, it was discovered that hydroxypropyl methylcellulose had greater mechanical film properties than the carboxymethyl cellulose, except for the folding endurance. Moreover, hydroxypropyl methylcellulose was shown to have a better disintegration time, which was in the range of 30 minutes to 90 minutes, with a drug release of 95% to 100%, while carboxymethyl cellulose disintegrated at 6 minutes to 15 minutes with a drug release of 60% to 75%. On the other hand, both solvent casting and spraying methods produced an evenly matched orally disintegrating film quality. Orally disintegrating films containing amlodipine besylate were developed and characterized. It was concluded that these orally disintegrating films have a great potential in the market and a profound ability in the reduction of geriatric non-c International Journal of Pharmaceutical Compounding (Ijpc) 2022 Article PeerReviewed application/pdf en http://irep.iium.edu.my/98713/7/98713_Comparison%20of%20solvent%20casting%20and%20spray%20casting%20method.pdf Ruslan, Mohamad Fariz Haiqal and Janakiraman, Ashok Kumar Janakiraman and Long, Chiau Ming and Helal Uddin, A.B.M. and Sarker, Zaidul Islam and Liew, Kai Bin (2022) Comparison of solvent casting and spray casting method on compounding of an orally disintegrating film containing amlodipine besylate. International Journal of Pharmaceutical Compounding, 26 (2). pp. 149-156. ISSN 1092-4221 |
institution |
Universiti Islam Antarabangsa Malaysia |
building |
IIUM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
International Islamic University Malaysia |
content_source |
IIUM Repository (IREP) |
url_provider |
http://irep.iium.edu.my/ |
language |
English |
topic |
QD Chemistry RM300 Drugs and their action RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry |
spellingShingle |
QD Chemistry RM300 Drugs and their action RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Ruslan, Mohamad Fariz Haiqal Janakiraman, Ashok Kumar Janakiraman Long, Chiau Ming Helal Uddin, A.B.M. Sarker, Zaidul Islam Liew, Kai Bin Comparison of solvent casting and spray casting method on compounding of an orally disintegrating film containing amlodipine besylate |
description |
The amlodipine besylate tablet is one of the most highly prescribed medicines to
manage hypertension in the geriatric population. However, the difficulty of swallowing
tablets due to problems like dysphagia, fear of choking, and odynophagia has been
identified as one of the contributing factors to non-compliance among geriatrics. Due to
the swallowing factor among geriatrics, this study was conducted to compare two compounding
methods of orally disintegrating films, namely solvent casting and spray
casting, to produce an orally disintegrating film containing amlodipine besylate. Different
polymers were used to develop the orally disintegrating films, and the formulations
were subjected to validation tests such as thickness, folding endurance, tensile strength,
percentage of elongation, Young’s modulus, disintegration, and dissolution. Chemicals
like hydroxypropyl methylcellulose, carboxymethyl cellulose, glycerin, mannitol,
sodium lauryl sulfate, citric acid, peppermint oil, and a coloring agent were used to formulate
the orally disintegrating films. In addition, orally disintegrating films were prepared
using the solvent casting and the spraying method. An increase in the polymer’s
concentration resulted in the formation of a greater mechanical strength. After a comparison
between the hydroxypropyl methylcellulose and the carboxymethyl cellulose as
film-forming agents, it was discovered that hydroxypropyl methylcellulose had greater
mechanical film properties than the carboxymethyl cellulose, except for the folding
endurance. Moreover, hydroxypropyl methylcellulose was shown to have a better disintegration
time, which was in the range of 30 minutes to 90 minutes, with a drug release
of 95% to 100%, while carboxymethyl cellulose disintegrated at 6 minutes to 15 minutes
with a drug release of 60% to 75%. On the other hand, both solvent casting and spraying
methods produced an evenly matched orally disintegrating film quality. Orally disintegrating
films containing amlodipine besylate were developed and characterized. It was
concluded that these orally disintegrating films have a great potential in the market and a
profound ability in the reduction of geriatric non-c |
format |
Article |
author |
Ruslan, Mohamad Fariz Haiqal Janakiraman, Ashok Kumar Janakiraman Long, Chiau Ming Helal Uddin, A.B.M. Sarker, Zaidul Islam Liew, Kai Bin |
author_facet |
Ruslan, Mohamad Fariz Haiqal Janakiraman, Ashok Kumar Janakiraman Long, Chiau Ming Helal Uddin, A.B.M. Sarker, Zaidul Islam Liew, Kai Bin |
author_sort |
Ruslan, Mohamad Fariz Haiqal |
title |
Comparison of solvent casting and spray casting
method on compounding of an orally disintegrating
film containing amlodipine besylate |
title_short |
Comparison of solvent casting and spray casting
method on compounding of an orally disintegrating
film containing amlodipine besylate |
title_full |
Comparison of solvent casting and spray casting
method on compounding of an orally disintegrating
film containing amlodipine besylate |
title_fullStr |
Comparison of solvent casting and spray casting
method on compounding of an orally disintegrating
film containing amlodipine besylate |
title_full_unstemmed |
Comparison of solvent casting and spray casting
method on compounding of an orally disintegrating
film containing amlodipine besylate |
title_sort |
comparison of solvent casting and spray casting
method on compounding of an orally disintegrating
film containing amlodipine besylate |
publisher |
International Journal of Pharmaceutical Compounding (Ijpc) |
publishDate |
2022 |
url |
http://irep.iium.edu.my/98713/7/98713_Comparison%20of%20solvent%20casting%20and%20spray%20casting%20method.pdf http://irep.iium.edu.my/98713/ |
_version_ |
1738510130401509376 |
score |
13.160551 |