Comparison of solvent casting and spray casting method on compounding of an orally disintegrating film containing amlodipine besylate
The amlodipine besylate tablet is one of the most highly prescribed medicines to manage hypertension in the geriatric population. However, the difficulty of swallowing tablets due to problems like dysphagia, fear of choking, and odynophagia has been identified as one of the contributing factors t...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Journal of Pharmaceutical Compounding (Ijpc)
2022
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/98713/7/98713_Comparison%20of%20solvent%20casting%20and%20spray%20casting%20method.pdf http://irep.iium.edu.my/98713/ |
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| Summary: | The amlodipine besylate tablet is one of the most highly prescribed medicines to
manage hypertension in the geriatric population. However, the difficulty of swallowing
tablets due to problems like dysphagia, fear of choking, and odynophagia has been
identified as one of the contributing factors to non-compliance among geriatrics. Due to
the swallowing factor among geriatrics, this study was conducted to compare two compounding
methods of orally disintegrating films, namely solvent casting and spray
casting, to produce an orally disintegrating film containing amlodipine besylate. Different
polymers were used to develop the orally disintegrating films, and the formulations
were subjected to validation tests such as thickness, folding endurance, tensile strength,
percentage of elongation, Young’s modulus, disintegration, and dissolution. Chemicals
like hydroxypropyl methylcellulose, carboxymethyl cellulose, glycerin, mannitol,
sodium lauryl sulfate, citric acid, peppermint oil, and a coloring agent were used to formulate
the orally disintegrating films. In addition, orally disintegrating films were prepared
using the solvent casting and the spraying method. An increase in the polymer’s
concentration resulted in the formation of a greater mechanical strength. After a comparison
between the hydroxypropyl methylcellulose and the carboxymethyl cellulose as
film-forming agents, it was discovered that hydroxypropyl methylcellulose had greater
mechanical film properties than the carboxymethyl cellulose, except for the folding
endurance. Moreover, hydroxypropyl methylcellulose was shown to have a better disintegration
time, which was in the range of 30 minutes to 90 minutes, with a drug release
of 95% to 100%, while carboxymethyl cellulose disintegrated at 6 minutes to 15 minutes
with a drug release of 60% to 75%. On the other hand, both solvent casting and spraying
methods produced an evenly matched orally disintegrating film quality. Orally disintegrating
films containing amlodipine besylate were developed and characterized. It was
concluded that these orally disintegrating films have a great potential in the market and a
profound ability in the reduction of geriatric non-c |
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