Effect of processing methods on xylitol-starch base co-processed adjuvant for orally disintegrating tablet application
Orally disintegrating tablet (ODT) is a friendly dosage form that requires no access to water and serves as a solution to non-compliance. There are many co-processed adjuvants available in the market. However, there is no single product possesses all the ideal characteristics such as good compre...
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Pakistan Journal of Pharmaceutical Sciences
2020
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my.iium.irep.825662022-11-07T02:21:20Z http://irep.iium.edu.my/82566/ Effect of processing methods on xylitol-starch base co-processed adjuvant for orally disintegrating tablet application Liew, Kai Bin Helal Uddin, A.B.M. Sarker, Md Zaidul Islam Manda, Uttam Kumar Gaurav, Anand QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Orally disintegrating tablet (ODT) is a friendly dosage form that requires no access to water and serves as a solution to non-compliance. There are many co-processed adjuvants available in the market. However, there is no single product possesses all the ideal characteristics such as good compressibility, fast disintegration and good palatability for ODT application. The aim of this research was to produce a xylitol-starch base co-processed adjuvant which is suitable for ODT application. Two processing methods namely wet granulation and freeze drying were used to compare the characteristics of co-processed adjuvant comprising of xylitol, starch and crospovidone XL-10 mixed at various ratios. The co-processed excipients were compressed into ODT and physically characterized for powder flow, particle size, hardness, thickness, weight, friability, in-vitro disintegration time and in-situ disintegration time, lubricant sensitivity, dilution potential, Fourier transform infrared spectroscopy, scanning electronic microscopy and x-ray diffraction analysis. Formulation F6 was selected as the optimum formulation due to the fastest in-vitro (135.33±11.52 s) and in-situ disintegration time (88.67±13.56s) among all the formulations (p<0.05). Increase in starch component decreases disintegration time of ODT. The powder flow fell under the category of fair flow. Generally, it was observed that freeze drying method produced smaller particle size granules compared to wet granulation method. ODT produced from freeze drying method had shorter disintegration time compared to ODT from wet granulation batch. In conclusion, a novel co- processed excipient comprised of xylitol, starch and crospovidone XL-10, produced using freeze drying method with fast disintegration time, good compressibility and palatability was developed and characterized. The co-processed excipient is suitable for ODT application. Pakistan Journal of Pharmaceutical Sciences 2020-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/82566/19/82566_Effect%20of%20processing%20methods%20on%20xylitol-starch.pdf application/pdf en http://irep.iium.edu.my/82566/20/82566_Effect%20of%20processing%20methods%20on%20xylitol-starch_Scopus.pdf Liew, Kai Bin and Helal Uddin, A.B.M. and Sarker, Md Zaidul Islam and Manda, Uttam Kumar and Gaurav, Anand (2020) Effect of processing methods on xylitol-starch base co-processed adjuvant for orally disintegrating tablet application. Pakistan Journal of Pharmaceutical Sciences, 33 (2). pp. 551-559. ISSN 1011-601X http://www.pjps.pk/wp-content/uploads/pdfs/33/2/Paper-7.pdf |
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QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Liew, Kai Bin Helal Uddin, A.B.M. Sarker, Md Zaidul Islam Manda, Uttam Kumar Gaurav, Anand Effect of processing methods on xylitol-starch base co-processed adjuvant for orally disintegrating tablet application |
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Orally disintegrating tablet (ODT) is a friendly dosage form that requires no access to water and serves as a
solution to non-compliance. There are many co-processed adjuvants available in the market. However, there is no single
product possesses all the ideal characteristics such as good compressibility, fast disintegration and good palatability for
ODT application. The aim of this research was to produce a xylitol-starch base co-processed adjuvant which is suitable
for ODT application. Two processing methods namely wet granulation and freeze drying were used to compare the
characteristics of co-processed adjuvant comprising of xylitol, starch and crospovidone XL-10 mixed at various ratios.
The co-processed excipients were compressed into ODT and physically characterized for powder flow, particle size,
hardness, thickness, weight, friability, in-vitro disintegration time and in-situ disintegration time, lubricant sensitivity,
dilution potential, Fourier transform infrared spectroscopy, scanning electronic microscopy and x-ray diffraction
analysis. Formulation F6 was selected as the optimum formulation due to the fastest in-vitro (135.33±11.52 s) and in-situ
disintegration time (88.67±13.56s) among all the formulations (p<0.05). Increase in starch component decreases
disintegration time of ODT. The powder flow fell under the category of fair flow. Generally, it was observed that freeze
drying method produced smaller particle size granules compared to wet granulation method. ODT produced from freeze
drying method had shorter disintegration time compared to ODT from wet granulation batch. In conclusion, a novel co-
processed excipient comprised of xylitol, starch and crospovidone XL-10, produced using freeze drying method with fast
disintegration time, good compressibility and palatability was developed and characterized. The co-processed excipient
is suitable for ODT application. |
format |
Article |
author |
Liew, Kai Bin Helal Uddin, A.B.M. Sarker, Md Zaidul Islam Manda, Uttam Kumar Gaurav, Anand |
author_facet |
Liew, Kai Bin Helal Uddin, A.B.M. Sarker, Md Zaidul Islam Manda, Uttam Kumar Gaurav, Anand |
author_sort |
Liew, Kai Bin |
title |
Effect of processing methods on xylitol-starch base co-processed
adjuvant for orally disintegrating tablet application |
title_short |
Effect of processing methods on xylitol-starch base co-processed
adjuvant for orally disintegrating tablet application |
title_full |
Effect of processing methods on xylitol-starch base co-processed
adjuvant for orally disintegrating tablet application |
title_fullStr |
Effect of processing methods on xylitol-starch base co-processed
adjuvant for orally disintegrating tablet application |
title_full_unstemmed |
Effect of processing methods on xylitol-starch base co-processed
adjuvant for orally disintegrating tablet application |
title_sort |
effect of processing methods on xylitol-starch base co-processed
adjuvant for orally disintegrating tablet application |
publisher |
Pakistan Journal of Pharmaceutical Sciences |
publishDate |
2020 |
url |
http://irep.iium.edu.my/82566/19/82566_Effect%20of%20processing%20methods%20on%20xylitol-starch.pdf http://irep.iium.edu.my/82566/20/82566_Effect%20of%20processing%20methods%20on%20xylitol-starch_Scopus.pdf http://irep.iium.edu.my/82566/ http://www.pjps.pk/wp-content/uploads/pdfs/33/2/Paper-7.pdf |
_version_ |
1751535892379467776 |
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13.160551 |