Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route
Abstract: Background: Most of the active pharmaceutical ingredients discovered recently in pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration of these drugs gets further complicated due to their short bioavailability,...
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my.iium.irep.586902018-03-20T02:51:23Z http://irep.iium.edu.my/58690/ Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route Chowdhury, Hira Gorain, Bapi Chatterjee, Bappaditya Mandal, Uttam Kumar Sengupta, Pinaki Tekade, Rakesh RS Pharmacy and materia medica Abstract: Background: Most of the active pharmaceutical ingredients discovered recently in pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration of these drugs gets further complicated due to their short bioavailability, inconsistent absorption and inter/intra subject variability. Methods: Pharmaceutical emulsion holds a significant place as a primary choice of oral drug delivery system for lipophilic drugs used in pediatric and geriatric patients. Pharmacokinetic studies on nanoemulsion mediated drugs delivery approach indicates practical feasibility in regards to their clinical translation and commercialization. Results: This review article is to provide an updated understanding on pharmacokinetic and pharmacodynamic features of nanoemulsion delivered via oral, intravenous, topical and nasal route. Conclusion: The article is of huge interest to formulation scientists working on range of lipophilic drug molecules intended to be administered through oral, intravenous, topical and nasal routes for vivid medical benefits. Keywords: Hydrophobicity, oral delivery, pharmacokinetics, pharmacodynamics, routes of administration. Bentham Science 2017-05 Article REM application/pdf en http://irep.iium.edu.my/58690/1/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features.pdf application/pdf en http://irep.iium.edu.my/58690/2/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/58690/3/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_WOS.pdf application/pdf en http://irep.iium.edu.my/58690/4/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_MYRA.pdf Chowdhury, Hira and Gorain, Bapi and Chatterjee, Bappaditya and Mandal, Uttam Kumar and Sengupta, Pinaki and Tekade, Rakesh (2017) Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route. Current Pharmaceutical Design, 23 (17). pp. 2504-2531. ISSN 1381-6128 http://www.eurekaselect.com/node/147857/article/pharmacokinetic-and-pharmacodynamic-features-of-nanoemulsion-following-oral-intravenous-topical-and-nasal-route 10.2174/1381612822666161201143600 |
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RS Pharmacy and materia medica Chowdhury, Hira Gorain, Bapi Chatterjee, Bappaditya Mandal, Uttam Kumar Sengupta, Pinaki Tekade, Rakesh Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route |
description |
Abstract: Background: Most of the active pharmaceutical ingredients discovered recently in pharmaceutical
field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration
of these drugs gets further complicated due to their short bioavailability, inconsistent absorption and inter/intra
subject variability.
Methods: Pharmaceutical emulsion holds a significant place as a primary choice of oral drug delivery system for
lipophilic drugs used in pediatric and geriatric patients. Pharmacokinetic studies on nanoemulsion mediated drugs
delivery approach indicates practical feasibility in regards to their clinical translation and commercialization.
Results: This review article is to provide an updated understanding on pharmacokinetic and pharmacodynamic
features of nanoemulsion delivered via oral, intravenous, topical and nasal route.
Conclusion: The article is of huge interest to formulation scientists working on range of lipophilic drug molecules
intended to be administered through oral, intravenous, topical and nasal routes for vivid medical benefits.
Keywords: Hydrophobicity, oral delivery, pharmacokinetics, pharmacodynamics, routes of administration. |
format |
Article |
author |
Chowdhury, Hira Gorain, Bapi Chatterjee, Bappaditya Mandal, Uttam Kumar Sengupta, Pinaki Tekade, Rakesh |
author_facet |
Chowdhury, Hira Gorain, Bapi Chatterjee, Bappaditya Mandal, Uttam Kumar Sengupta, Pinaki Tekade, Rakesh |
author_sort |
Chowdhury, Hira |
title |
Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route |
title_short |
Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route |
title_full |
Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route |
title_fullStr |
Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route |
title_full_unstemmed |
Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route |
title_sort |
pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route |
publisher |
Bentham Science |
publishDate |
2017 |
url |
http://irep.iium.edu.my/58690/1/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features.pdf http://irep.iium.edu.my/58690/2/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_SCOPUS.pdf http://irep.iium.edu.my/58690/3/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_WOS.pdf http://irep.iium.edu.my/58690/4/58690_Pharmacokinetic%20and%20Pharmacodynamic%20Features_MYRA.pdf http://irep.iium.edu.my/58690/ http://www.eurekaselect.com/node/147857/article/pharmacokinetic-and-pharmacodynamic-features-of-nanoemulsion-following-oral-intravenous-topical-and-nasal-route |
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1643615412197261312 |
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13.159267 |