Synthesis, antiphospholipase A2, antiprotease, antibacterial evaluation and molecular docking analysis of certain novel hydrazones

• Main Authors: El-Sayed, Nahed Nasser Eid, Alafeefy, Ahmed Mahmoud, Bakht, Mohammed Afroz, Vijay H., Masand, Aldalbahi, Ali, N., Chen, C., Fan, Bacha, Abir Ben Ben
• Format: Article
• Language: English; English
• Published: MDPI AG 2016
• Subjects: RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/56527/1/56527_Synthesis%2C%20antiphospholipase%20A2%2C%20antiprotease.pdf; http://irep.iium.edu.my/56527/2/56527_Synthesis%2C%20antiphospholipase%20A2%2C%20antiprotease_Scopus.pdf; http://irep.iium.edu.my/56527/; http://www.mdpi.com/1420-3049/21/12/1664/pdf

Some novel hydrazone derivatives 6a-o were synthesized from the key intermediate 4-Chloro-N-(2-hydrazinocarbonyl-phenyl)-benzamide 5 and characterized using IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. The inhibitory potential against two secretory phospholipase A2 (sPLA2), three p...