Synthesis and evaluation of anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities of some 3H-quinazolin-4-one derivatives

• Main Authors: El-Sayed, Nahed Nasser Eid, Almaneai, Norah M., Ben Bacha, Abir G., Al-Obeed, Omar A., Ahmad, Rehan, Abdulla, Maha Hamadien, Alafeefy, Ahmed Mahmoud
• Format: Article
• Language: English; English; English
• Published: Taylor & Francis 2019
• Subjects: QD Chemistry; RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/72704/19/72704_Synthesis%20and%20evaluation%20of%20anticancer_article.pdf; http://irep.iium.edu.my/72704/2/72704_Synthesis%20and%20evaluation%20of%20anticancer_scopus.pdf; http://irep.iium.edu.my/72704/3/72704_Synthesis%20and%20evaluation%20of%20anticancer_wos.pdf; http://irep.iium.edu.my/72704/; https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1574780

Some new 3H-quinazolin-4-one derivatives were synthesised and screened for anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities. Compound 15d was more potent in reducing the cell viabilities of HT-29 and SW620 cells lines to 38%, 36.7%, compared to 5-FU which demonstr...