Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells

• Main Authors: Rostam, Muhamad Ashraf, Piva, Terence J., Osman, Narin, Little, Peter J.
• Format: Conference or Workshop Item
• Language: English; English
• Published: 2013
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/55300/1/Print_Ashraf_AVBS%20Poster%20030913.pdf; http://irep.iium.edu.my/55300/7/FINAL%20Program%20for%20AVBS_ANZMS%202013.pdf; http://irep.iium.edu.my/55300/

The pre-inflammatory stage of atherosclerosis is associated with proteoglycan glycosaminoglycan (GAG) chain hyperelongation that results in increased proteoglycan binding to low density lipoprotein (LDL). Transforming Growth Factor-β (TGF-β) is closely associated with atherosclerosis and mediates GA...