Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal

• Main Authors: Osthoff, Michael, Siegemund, Martin, Balestra, Gianmarco, Abdul Aziz, Mohd. Hafiz, Roberts, Jason A.
• Format: Article
• Language: English; English; English
• Published: EMH Swiss Medical Publishers Ltd 2016
• Subjects: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/52327/1/smw-2016-14368.pdf; http://irep.iium.edu.my/52327/7/52327-Prolonged%20administration%20of%20%CE%B2-lactam%20antibiotics_SCOPUS.pdf; http://irep.iium.edu.my/52327/8/52327-Prolonged%20administration%20of%20%CE%B2-lactam%20antibiotics_WOS.pdf; http://irep.iium.edu.my/52327/

Prolonged infusion of β-lactam antibiotics as either extended (over at least 2 hours) or continuous infusion is increasingly applied in intensive care units around the world in an attempt to optimise treatment with this most commonly used class of antibiotics, whose effectiveness is challenged by in...