Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

• Main Authors: Roberts, Jason A., Abdul Aziz, Mohd. Hafiz, Lipman, Jeffrey, Mouton, Johan W., Vinks, Alexander A., Felton, Timothy W., Hope, William W., Farkas, Andras, Neely , Michael N., Schentag, Jerome J., Drusano, George, Frey, Otto R., Theuretzbacher, Ursula, Kuti, Joseph L.
• Format: Article
• Language: English
• Published: Elsevier 2014
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/36783/1/14733099-S1473309914X70702-S1473309914700362-main.pdf; http://irep.iium.edu.my/36783/; http://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2814%2970036-2/abstract

Infections in critically ill patients are associated with persistently poor clinical outcomes. These patients have severely altered and variable antibiotic pharmacokinetics and are infected by less susceptible pathogens. Antibiotic dosing that does not account for these features is likely to result...