Exposure-effect relationship of mycophenolic acid and prednisolone in adult patients with lupus nephritis

• Main Authors: Abd. Rahman, Nurul Azrin, Tett, Susan E., Abdul Gafor, Abdul Halim, McWhinney, Brett, Staatz, Christine E.
• Format: Article
• Language: English
• Published: John Wiley & Sons, Inc. 2015
• Subjects: RM300 Drugs and their action; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/44995/4/Rahman_et_al-2015-British_Journal_of_Clinical_Pharmacology.pdf; http://irep.iium.edu.my/44995/; http://onlinelibrary.wiley.com/doi/10.1111/bcp.12678/abstract;jsessionid=AABBE5A02EE3E0C36FF879312BBDBB41.f02t03

The aim was to examine relationships between total and unbound mycophenolic acid (MPA) and prednisolone exposure and clinical outcomes in patients with lupus nephritis. METHODS: Six blood samples were drawn pre- and at 1, 2, 4, 6 and 8 h post-dose and total and unbound MPA and prednisolone pre-dos...