An S188V mutation alters substrate specificity of non-stereospecific α-haloalkanoic acid dehalogenase E (DehE)
The non-stereospecific α-haloalkanoic acid dehalogenase E (DehE) degrades many halo- genated compounds but is ineffective against β-halogenated compounds such as 3- chloropropionic acid (3CP). Using molecular dynamics (MD) simulations and site-directed mutagenesis we show here that introducing th...
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Main Authors: | Abdul Hamid, Azzmer Azzar, Tengku Abdul Hamid, Tengku Haziyamin, Abdul Wahab, Roswanira, Shamsir, Mohd Shahir, Huyop, Fahrul Zaman |
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Format: | Article |
Language: | English |
Published: |
The Public Library of Science (PLoS)
2015
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Subjects: | |
Online Access: | http://irep.iium.edu.my/42599/1/42599.pdf http://irep.iium.edu.my/42599/ http://www.plosone.org/ |
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